Absolute Configuration of In Situ Crystallized (+)-γ-Decalactone

Knowledge about the absolute configuration of small bioactive organic molecules is essential in pharmaceutical research because enantiomers can exhibit considerably different effects on living organisms. X-ray crystallography enables chemists to determine an enantiopure compound due anomalous dispersion. Here, we present determination flavoring agent (+)-γ-decalactone, which liquid under ambient conditions. Single crystals were grown from a glass capillary by situ cryo-crystallization. Diffraction data collection was performed using Cu-Kα radiation. The confirmed. molecule consists linear aliphatic non-polar backbone and polar lactone head. In solid state, layers sections alternating along c-axis unit cell are observed. favorable cases, this method pure (bioactive) agents or products asymmetric catalysis convenient alternative conventional methods structure determination, such as optical rotatory dispersion, vibrational circular dichroism, ultraviolet-visible spectroscopy, use chiral shift reagents proton NMR Coulomb explosion imaging.